Consolidating new memories requires the amygdala and

These studies were accompanied by the creation of animal models of human amnesia in an effort to identify brain substrates critical for slow consolidation.

Molaison also showed signs of retrograde amnesia spanning a period of about 3 years prior to the surgery suggesting that recently acquired memories of as long as a couple years could remain in the MTL prior to consolidation into other brain areas.

Research into other patients with resections of the MTL have shown a positive relationship between the degree of memory impairment and the extent of MTL removal which points to a temporal gradient in the consolidating nature of the MTL.

and occurs within the first few hours after learning, and systems consolidation, where hippocampus-dependent memories become independent of the hippocampus over a period of weeks to years.

Recently, a third process has become the focus of research, reconsolidation, in which previously-consolidated memories can be made labile again through reactivation of the memory trace.

Memory consolidation was first referred to in the writings of the renowned Roman teacher of rhetoric Quintillian. that the interval of a single night will greatly increase the strength of the memory,” and presented the possibility that “… undergoes a process of ripening and maturing during the time which intervenes.” The process of consolidation was later proposed based on clinical data illustrated in 1882 by Ribot’s Law of Regression, “progressive destruction advances progressively from the unstable to the stable”. Burnham a few years later in a paper on amnesia integrating findings from experimental psychology and neurology.

Search for consolidating new memories requires the amygdala and:

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Coining of the term “consolidation” is credited to the German researchers Müller and Alfons Pilzecker who rediscovered the concept that memory takes time to fixate or undergo “Konsolidierung” in their studies conducted between 18.

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